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doi: 10.3389/fcimb.2024.1328419 43 De AngelisCNardoneAGarifalosFPivonelloCSansoneAConfortiAet al

Classification of AC Separations AC separations are classified into six types (Type I to Type VI) based on the severity of ligament damage and degree of separation: Type I: Minor sprain with no displacement Type II: Partial dislocation with rupture of the AC ligament Type III: Complete dislocation with tearing of both AC and coracoclavicular (CC) ligaments Types IV-VI: Severe dislocations involving displacement of the clavicle in various directions, typically requiring surgery Types I to III are typically managed conservatively, whereas Types IV to VI may require surgical intervention

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Co-lyophilization ensures precise stoichiometric ratios between the two peptides, eliminating the variability that can occur when reconstituting and mixing separate vials