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True or Longitudinal Melanonychia (LM) Melanocytes are sparsely distributed in the nail bed (approximately 50/mm2) and in the nail matrix (200/mm2), with higher activity observed in the distal matrix (L-DOPA positive).2,1519 These cells are typically quiescent in Caucasians and can become active due to various physiological and pathological conditions, or through drugs.17,20 The number of melanocytes in the proximal matrix is equivalent to that in the distal matrix

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Tirzepatide is designed as a once-weekly injection