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Researchers comment that there does not appear to be data to suggest that using GLP-1 receptor agonists may cause weight gain, nor may have any indication that they increase the risk of hypoglycemia

Peptides: Structure, Function, Peptide Synthesis & Research Applications Peptides are short chains of amino acids linked by peptide bonds, typically 2 to 50 residues long, and are fundamental to cell biology, distinguishing them from longer polypeptides

Regulatory Toxicology and Pharmacology Journal 2006;46(1):23-28

The medication does not replace hormone therapy but instead addresses the metabolic dysfunction that accompanies estrogen loss