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There are also experimental studies suggesting the ability of helminths to ameliorate symptoms of autoimmune diseases such as TNBS-induced colitis, arthritis, and psoriasis [26,27,28,29,30]

FDA Approval Timeline: From NDA to Market Launch NDA Submission: Q4 2026 Eli Lilly will compile efficacy data primarily from TRIUMPH-1, supportive data from TRIUMPH-4, the safety database across all trials, and manufacturing/labeling documentation

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Concurrently, GLP-1 enhances SIRT1 expression, which deacetylates the RelA/p65 subunit of NF-B to limit its nuclear translocation, suppressing IL-1 and TNF- at the transcriptional level