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Injectable administration further magnifies this risk by introducing the possibility of local tissue reaction, systemic inflammatory exposure, and contamination-related complications

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A two-sided P -value of .05, or not containing a null value (SMD = 0) within the 95% CI was considered to be significant

Manganese potentiates nuclear factor-kappab-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways