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There's no evidence that you build tolerance to BPC-157, but cycling off periodically is still considered good practice

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10.1074/jbc.M111.253039 Summary Keywords stable gastric pentadecapeptide BPC 157, fistula, bleeding disorder, concept practical applicability, wound healing Citation Seiwerth S, Milavic M, Vukojevic J, Gojkovic S, Krezic I, Vuletic LB, Pavlov KH, Petrovic A, Sikiric S, Vranes H, Prtoric A, Zizek H, Durasin T, Dobric I, Staresinic M, Strbe S, Knezevic M, Sola M, Kokot A, Sever M, Lovric E, Skrtic A, Blagaic AB and Sikiric P (2021) Stable Gastric Pentadecapeptide BPC 157 and Wound Healing

If this is a minor nuisance, one can brace their knee for these types of activities to see if that helps them increase their overall function