Kidney stones are made of struvite, which is magnesium ammonium phosphate, in 17% of cases
Consistently, they reduce DHA into ascorbate with a better efficiency ( k cat around 10 4 s 1 , k cat / K m around 10 7 M 1 .s 1 ) compared to the other enzymes ( k cat around 10 2 s 1 ) and to the reduction of glutathionylated-mercaptoethanol, the product formed upon incubation between GSH and HED ( k cat around 10 2 s 1 ) (Table 5) (Dixon et al., 2003)
Furthermore, CPN-9, a novel NRF2 activator, is neuroprotective against mutant SOD1 H46R motor deficits and disease progression in mice (Kanno et al., 2012)
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