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Increasing recognition of these metabolic abnormalities has driven interest in repurposing antidiabetic therapies, particularly glucagon-like peptide-1 (GLP-1) and GLP-1 receptor agonists (GLP-1RAs), for ALS

If these factors are absent, continuation may be appropriate

If the results do not allow for the precise identification of a genetic aetiology, and, still, the age of onset, extrahepatic manifestations, and family history of jaundice or ICP all point towards inherited cholestasis, a thorough investigation such as WES allows a high percentage of patients to reach a diagnosis

We worry about the drug causing hemolysis [the breakdown of red blood cells] in people who have congenital deficiency of G6PD, says Charles Abrams, MD, director of the Penn-CHOP Blood Center in Philadelphia