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Catalytic Activities of DPP4 DPP4 has a post-proline dipeptidyl amino peptidase activity, preferentially cleaving Xaa-Pro dipeptides (where Xaa refers to any amino acid) from oligopeptides

Accordingly, culturing human islets in the presence of a DPP-4 inhibitor resulted in increased levels of intact GLP-1 ( Collectively, the results discussed above could be interpreted to suggest that conditions likely to result in -cell stress, such as obesity, hyperglycaemia, and inflammation, activate compensatory responses in an attempt to improve -cell function and survival