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Typical loading phase protocols: Daily injections for the first week Weekly injections for the next 4-6 weeks This intense schedule quickly boosts B12 levels

Once phosphorylated, HSL appears to expose more hydrophobic regions

Due to its safety, acetaminophen is prescribed for patients in whom non-steroidal anti-inflammatory drugs (NSAIDs) are contraindicated, such as those with gastric ulcers and bronchial asthma, pregnant women, nursing mothers, and children (Roberts et al., 2016)

In the primary efficacy phase (months 0-6), patients were randomly assigned to receive tesamorelin [2 mg subcutaneous (SC) every day] or placebo in a 2:1 ratio