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Zinc and copper are known cofactors for thyroid hormone metabolism and antioxidant defense systems, which may explain the pronounced response in the ZnO-NPs and Cu-NPs groups 83

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Subjectively all patients reported significant improvement in their symptoms which, according to them, far surpassed the benefit they had experienced with prior medication and heat treatments without Meibomian gland probing and Exosome therapy

Disease states that affect intra-portal insulin levels by increasing insulin resistance causing compensatory intra-portal hyperinsulinemia or by decreasing pancreatic -cell insulin secretion causing intra-portal hypoinsulinemia results in changes to hepatic IGF-I synthesis and secretion, and consequently changes in GH levels via the negative feedback loop