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The GLP-1 era represents a genuine step change in what medicine can achieve for people with obesity

Vehicle IGF-1 (5 nM) or IGF-2 (20 nM) was then added to the media for 2 min and cells were then rapidly lysed in ice-cold buffer to assess receptor activation as described below

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Cardiovascular outcome trials (including LEADER, SUSTAIN-6, REWIND, and SELECT) have demonstrated that certain GLP-1 receptor agonists reduce major adverse cardiovascular events in patients with established cardiovascular disease or multiple risk factors