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This suggests that the observed activation in many brain regions is indirect likely triggered by the drug binding in more accessible areas, such as the circumventricular organs, which then transmit signals to other parts of the brain

Bile duct ligation increased dopamine levels in the cerebral cortex of rats partly due to induction of tyrosine hydroxylase

Dosing typically begins at a lower dose, suggested initiation of 4 units (0.04 mL) weekly for the first 4 weeks, then escalates according to a titration schedule: Weeks 1-4: Inject 4 units (0.04 mL) one time per week Weeks 5-8: Inject 8 units (0.08 mL) one time per week Weeks 9-12: Inject 18 units (0.18 mL) one time per week Weeks 13-16: Inject 30 units (0.3 mL) one time per week Week 16+: Inject 44 units (0.44 mL) one time per week Dosing may deviate from this pattern to accommodate patient-specific needs

This once-weekly treatment supports metabolic balance as part of a structured 12-month care plan