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PRMT9 then targets heat shock protein family A member 8 (HSPA8) and enhances arginine methylation at residues R76 and R100

Consistent with this function, it has been shown that APAP induces autophagy both in primary mouse hepatocytes and intact liver and therefore the pharmacological promotion of autophagy by rapamycin protects against APAP hepatotoxicity (Ni et al., 2012a, 2013)

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Another phase II randomized pilot study that aimed to evaluate the same melanotan I implant and narrow-band ultraviolet B (NB-UVB) light was also published in 2011