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[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Candelli M., Franza L., Pignataro G., Ojetti V., Covino M., Piccioni A., Gasbarrini A., Franceschi F

Briefly, when muscle is injured, overused, or mechanically stretched, satellite cells are activated to enter the cell cycle through a cascade of events including nitric oxide (NO) radical-dependent release of the active form of HGF (a hetero-dimer of - and -chains) from its extracellular tethering and the subsequent presentation of HGF to the cell-membrane signaling receptor c-met, followed by the sequence of steps including proliferation to produce myoblast progeny, differentiation, and fusion with existing muscle fibers and/or to form new fibers 18,19,20,21,22, 31

doi: 10.3390/antiox9030235 13 HinsvarkO