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Intensive insulin therapy Although insulin resistance is a major contributor to the development of NAFLD in most cases [40], insulin therapy has not been proved to resolve or improve NAFLD

The Standards of Medical Care in Diabetes, updated annually, includes dedicated sections on incretin-based therapies relevant for understanding tirzepatide pharmacology and clinical application

While these results are highly encouraging, robust, large-scale human clinical trials are still needed to validate these effects and establish a definitive therapeutic profile in humans

Activation of the GLP-1 receptor initiates a series of cascading reactions, which exert a hypoglycemic effect by stimulating insulin secretion from pancreatic -cells and inhibiting glucagon secretion from -cells, thereby reducing the stimulatory effect of glucagon on gluconeogenesis in the liver (Figure 2)