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Mast Cell Activation Syndrome Treatment Conventional treatment for mast cell activation syndrome generally involves the use of pharmaceutical and over-the-counter medications to alleviate symptoms, such as the following medications: Epinephrine (such as an EpiPen) for severe reactions First generation H1 blockers diphenhydramine (Benadryl) and hydroxyzine (Vistaril) Second generation H1 blockers, including loratadine (Claritin), cetirizine (Zyrtec), and fexofenadine (Allegra) H2 blockers, such as ranitidine (Zantac) and famotidine (Pepcid) Aspirin, to block production of prostaglandin D2 and reduce flushing

DeGregorio-Rocasolano, N

Furthermore, it has been found that modulation of the Nrf2 signalling pathway by triterpenoids compounds results in a significant increase in survival in the SOD1 G93A mouse model of ALS, thereby indicating that activation of Nrf2 has a neuroprotective effect [268]

At this stage, researchers study how well the treatment works and how safe it is in a much larger group of people over a longer period