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The P-SNO can be reconverted to P-SH by thiol-dependent systems, among which GSH plays a prominent role through the translocation reaction of NO that generates GSNO [18,21] (Figure 2)

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Monitoring for side effects is crucial, especially when combining treatments

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Be aware that NICE guidance (TA875) specifies that Wegovy should be prescribed through specialist weight management services and treatment is limited to a maximum of 2 years

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