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The trial's primary insulin-sensitivity endpoint was null across the whole group, with benefits appearing in subgroups such as people with low baseline Akkermansia and those with prediabetes ( Suenaert et al., 2026 )

More severe side effects include pancreatitis (inflammation of the pancreas), gallbladder issues, and potential interactions with other medications

Research shows that patients who develop healthy habits alongside medication tend to maintain more weight loss after stopping

Joint pain (arthralgia) is not generally recognised as a common class-wide side effect of GLP-1 receptor agonists, though individual product profiles vary