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The obtained results demonstrate the capability of PEGylated NLCs to improve the oral bioavailability of antibiotics and their effectiveness in treating MRSA skin infections [154]

MS data were analyzed using MaxQuant software version 1.3.0.5 and were searched against the UniProtKB database

2.3 Ferroptosis defense mechanisms 2.3.1 System X c /GSH/GPX4 axis The System X c /GSH/GPX4 axis, DHODHubiquinol (CoQH 2 ) system, FSP1CoQ10 axis, GTP cyclohydrolase-1 (GCH1)tetrahydrobiopterin (BH4) axis, and sex hormones can inhibit ferroptosis, and the inhibition of related molecular pathways is an important strategy to induce ferroptosis in tumor cells (45)