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Despite the efficacy of MTX, related toxicity has been reported in several studies, including liver toxicity (increase of liver function, risk of liver failure), kidney toxicity (renal impairment, renal failure), hematological toxicity (pancytopenia, myelosuppression, leukopenia, neutropenia, megaloblastic anemia), pulmonary toxicity (wheezing, asthma), dermatological toxicity (skin lesion), and gastrointestinal (GI) effects (diarrhea, nausea, vomiting, etc

These results were sustained for 12 weeks after treatment

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Vitamin B12 (cyanocobalamin) is a water-soluble cofactor at the centre of cellular energy metabolism, the methylation cycle, DNA synthesis and red-blood-cell formation one of the most fundamental molecules in metabolic research[1]