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Based mainly on receptor transcript expression in the nodose ganglia, where the cell bodies of vagal afferents reside, and nerve transection studies, endogenous gut hormones including ghrelin [23], cholecystokinin (CCK) [24, 25], GLP-1 [26], and peptide YY 336 (PYY 336 ) [27] are thought to control food intake via their interaction with vagal afferents in a paracrine manner

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This trend aligns with national dispensing patterns, where a study reported a nearly 600% increase in GLP-1 RA prescription fills among adolescents and young adults from 2020 to 2023 ( 9 ) and our own research, which has shown that GLP-1 RAs now make up over 5% of all prescriptions prescribed