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Approval: 2017

Too much methionine can lower both Hcy and GSH, leading to more free radicals and damage to DNA, RNA, and mitochondria

[8] Patients with significant alcohol intake or thiamine deficiency also require precaution: chronic heavy alcohol use can deplete thiamine (vitamin B) and taking ALA in the setting of thiamine deficiency has been associated with serious health risks (including a condition resembling Wernickes encephalopathy)