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Here, we describe the design of the phase 3 evoke and evoke+ trials, the first trials to investigate the efficacy, safety, tolerability, and potential disease-modifying effect of oral semaglutide up to 14 mg versus placebo in participants with early-stage symptomatic AD (MCI or mild dementia)
doi: 10.1136/bmj.38933.585764.AE 110 PerrinRRisteLHannMWaltherAMukherjeeAHealdA
This dual mechanism means patients may experience declining blood pressure readings within weeks of starting tirzepatide, even before major weight loss occurs
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