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the mechanism is not established and may reflect neuroimmune or vasodilatory effects, though this remains speculative Photosensitivity : a small number of individuals have reported increased sensitivity to sunlight

310 The kidneys susceptibility to oxidative stress stems from various sources including the mitochondrial respiratory complex, NADPH oxidases, endothelial nitric oxide synthase (eNOS), myeloperoxidase, and xanthine oxidoreductase (XOR), all of which contribute to the advancement of chronic kidney disease and its related complications

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When the mast cells degranulate, they release many mediators including histamine, which as discussed above, is believed to cause flushing through its vasodilatory effect on vascular smooth muscle