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These core pathophysiological components exhibit intricate bidirectional crosstalk, operating through mutually reinforcing mechanisms that collectively perpetuate the syndromes phenotypic heterogeneity and clinical progression ( Figure 1 )

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You can use all three, but they must be applied at different times of day

Therefore, NPs are specially designed to facilitate their transport across the BBB and provide therapeutic effects against certain neurological diseases like AD, PD, stroke, and brain tumors [241]