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Sensitivity analyses were also performed using eGFR calculated determined using the 2021 creatinine-based CKD-EPI formula 43 , and separately using the combined creatinine-cystatin C CKD-EPI formula (Supplementary Appendix 2) 19

For instance, excessive fluid intake beyond normal hydration needs does not enhance the breakdown of peptide-based medications like tirzepatide and could lead to electrolyte imbalances

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[PMC free article: PMC2110476] [PubMed: 229107] 45