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Together with the osmotic pressure created by cilia-tethered mucins and the apical epithelial membrane (about 180 Pa), this pressure steadily draws water from the underlying epithelial cells into the airway lining fluid, supporting the replacement of water lost through evaporation as the airways humidify inhaled air 1

PrPdeficient cerebellar neurons show impaired survival after exposure to hypoxia or treatments with glutamate or H 2 O 2 , while PrPdeficient astrocytes have enhanced GSH contents and show accelerated GSH export and reduced GT activity (Guitart et al

But they are animal and cell work

This becomes more relevant with extended use, typically after several months