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On the other hand, no statistical significance was noted for Ki-67, H3K9ac, H3K18ac, HDAC3, HDAC6, and p21 levels in benign, DCIS, or IDC tissues following SFN intervention, which might be explained by the short duration of intervention ( In melanoma, there was no significant correlation between the administration of three different concentrations of oral SFN (50, 100, and 200 mol) once daily for 28 days and changes in proinflammatory cytokines ( None of the studies reported significant adverse effects, which may support the safety profile of SFN and its feasibility as a potential future chemotherapeutic molecule